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lumacaftor/ivacaftor will decrease the extent or effect of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 inducers lessens plasma focus of abemaciclib and its metabolites.), which permits Many others to distribute the do the job, furnishe